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SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Kill Dhengzky by Kill Dhengzky
January 28, 2022
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  • Bioinformatics Unit, Division of Infectious Sicknesses, Nationwide Institute of Well being Doutor Ricardo Jorge (INSA), Lisbon, Portugal

    Vítor Borges, Joana Isidro & João Paulo Gomes

  • Department of Global Epidemiology and Inhabitants Research, Fogarty Global Heart, Nationwide Institutes of Well being, Bethesda, MD, USA

    Nídia Sequeira Trovão

  • Innovation and Generation Unit, Division of Human Genetics, Nationwide Institute of Well being Doutor Ricardo Jorge (INSA), Lisbon, Portugal

    Sílvia Duarte, Hugo Martiniano & Luís Vieira

  • Reference and Surveillance Unit, Division of Infectious Sicknesses, Nationwide Institute of Well being Doutor Ricardo Jorge (INSA), Lisbon, Portugal

    Helena Cortes-Martins

  • Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal

    Isabel Gordo, Ricardo Leite, Cathy Paulino, João Costa, João Sobral & Susana Ladeiro

  • Centre for Toxicogenomics and Human Well being (ToxOmics), Genetics, Oncology and Human Toxicology, Nova Scientific College; Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

    Luís Vieira

  • Nationwide Reference Laboratory for Influenza and different Respiration Viruses, Division of Infectious Sicknesses, Nationwide Institute of Well being Doutor Ricardo Jorge (INSA), Lisbon, Portugal

    Raquel Guiomar

  • Centro Hospitalar de Vila Nova de Gaia e Espinho, Vila Nova de Gaia, Portugal

    Agostinho José S. Lira, Filomena Lacerda, Jorge Meneses, Maria Matos Figueiredo, Nair Seixas & Paulo Leandro

  • Laboratório Regional de Saúde Pública Drª Laura Ayres – ARS Algarve, Almancil, Portugal

    Aida M. Sousa Fernandes

  • Serviço de Patologia Clínica, Health center de Braga, Braga, Portugal

    Alexandra Estrada & Fernando Branca

  • Instituto Nacional de Saúde Dr Ricardo Jorge (INSA), Lisboa, Portugal

    Alexandra Nunes, Ana Pelerito, Anabela Vilares, Baltazar Nunes, Carla Feliciano, Carla Roque, Célia Rodrigues Bettencourt, Constantino P. Caetano, Cristina Correia, Cristina Veríssimo, Elizabeth Pádua, Fátima Martins, Fernanda Vilarinho, Idalina Ferreira, Inês Costa, Isabel Lopes de Carvalho, Ivone Água-Doce, Jorge Machado, José Vicente Constantino, Leonor Silveira, Líbia Zé-Zé, Márcia Faria, Margarida Vaz, Maria João Gargate, Maria José Borrego, Mónica Oleastro, Nuno Verdasca, Patrícia Barros, Paula Bajanca-Lavado, Paula Palminha, Pedro Pechirra, Raquel Neves, Raquel Rocha, Raquel Rodrigues, Raquel Sabino, Rita Cordeiro, Rita de Sousa, Rita Macedo, Rita Matos, Sílvia Lopo, Sónia Silva, Susana Martins, Susana Silva & Vera Manageiro

  • Beatriz Godinho Saúde, Leiria, Portugal

    Alfredo Rodrigues & Maria Beatriz Tomaz

  • Serviço de Patologia Clínica, Centro Hospitalar Tondela-Viseu, Viseu, Portugal

    Ana Caldas, Isabel Albergaria & Margarida Farinha

  • Serviço de Microbiologia, Centro Hospitalar do Porto, Porto, Portugal

    Ana Constança & Maria Helena Ramos

  • Instituto Nacional de Investigação Agrária e Veterinária, Lisboa, Portugal

    Ana Margarida Henriques, Miguel Fevereiro & Tiago Luís

  • Laboratório de Análises Clínicas da Universidade de Coimbra, Coimbra, Portugal

    Ana Miguel Matos

  • ACES de Baixo Vouga, Administração Regional de Saúde do Centro, Aveiro, Portugal

    Ana Oliveira & Regina Sá

  • Laboratório de Microbiologia e Biologia Molecular do Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal

    Ana Paula Dias, Cristina Toscano, João Dias & Maria Ana Pessanha

  • Serviço Especializado de Epidemiologia e Biologia Molecular, Health center de Santo Espírito, Ilha Terceira, Açores, Angra do Heroísmo, Portugal

    Ana Rita Couto & Jácome Bruges Armas

  • Unidade Native de Saúde de Matosinhos, Matosinhos, Portugal

    António Albuquerque & Valquíria Alves

  • Interactive Applied sciences Institute – LARSyS, Funchal, Portugal

    Bruna R. Gouveia & João Rodrigues

  • Centro de Investigação de Montanha, Instituto Politécnico de Bragança, Bragança, Portugal

    Carina de Fátima Rodrigues & Maria Alice Pinto

  • Laboratório de Análises Clínicas Dr Joaquim Chaves, Lisboa, Portugal

    Carlos Cardoso & Pedro Cardoso

  • Laboratório De Biologia Molecular da Unilabs, Porto, Portugal

    Carlos Sousa

  • Unidade de Genética e Patologia Moleculares, Health center do Divino Espirito Santo de Ponta Delgada, Ilha de S. Miguel, Açores, Ponta Delgada, Portugal

    Claudia C. Branco, Luisa Mota-Vieira & Rita C. Veloso

  • Centro de Estudos de Doenças Crónicas, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal

    Cláudia Nunes dos Santos & Paulo Pereira

  • Laboratório Biologia Molecular- Serviço de Patologia Clínica, Centro Hospitalar Universitário Lisboa Central, Lisboa, Portugal

    Conceição Godinho, Isabel Dias, Isabel Fernandes, Lidia Santos, Lurdes Lopes, Olga Costa, Patricia Miguel, Paula Branquinho, Paula Soares, Rita Côrte-Actual & Sónia Rodrigues

  • ALS Controlvet, Tondela, Portugal

    Daniela Silva & Inês Gomes

  • Centro Médico da Praça, São João da Madeira, Portugal

    Diana Patrícia Pinto da Silva & Ricardo Filipe Romão Ferreira

  • Serviço de Patologia Clínica, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Actual, Portugal

    Eliana Costa & Sara Sousa

  • Serviço de Patologia Clínica, Unidade Native de Saúde da Guarda, Guarda, Portugal

    Fátima Vale, Joana Ramos, Nelson Ventura, Patricia Fonseca & Rita Gralha

  • Health center Espírito Santo, Évora, Portugal

    Filomena Caldeira

  • Laboratório Dra Helena Rodrigues, Valença, Portugal

    Francisca Rocha & Helena Rodrigues

  • Serviço de Patologia Clínica – Health center Dr. Nélio Mendonça – SESARAM, Funchal, Portugal

    Graça Andrade, José Alves & Ludivina Freitas

  • Serviço de Patologia Clínica, Health center de Vila Franca de Xira, Vila Franca de Xira, Portugal

    Helena Ribeiro, Luís Silva, Rita Rodrigues & Teresa Salvado

  • Instituto de Administração da Saúde da Madeira, Funchal, Portugal

    Herberto Jesus & Maurício Melim

  • Serviço de Virologia, Instituto Português de Oncologia do Porto, Porto, Portugal

    Hugo Sousa & Inês Baldaque

  • Serviço de Patologia Clinica – Unidade Native de Saúde Litoral Alentejano, Santiago do Cacém, Portugal

    Inna Slobidnyk

  • Existence and Well being Sciences Analysis Institute, College of Medication, College of Minho, Braga, Portugal

    João Carlos Sousa & Maria Isabel Veiga

  • Synlab, Lisboa, Portugal

    Laura Brum

  • Secção de Patologia Molecular, Synlab, Lisboa, Portugal

    Lurdes Monteiro

  • Centro Hospitalar Tâmega e Sousa, Penafiel, Portugal

    Maria Calle Vellés & Mariana Viana

  • Serviço de Imunohemoterapia, Unidade Native de Saúde do Alto Minho, Viana do Castelo, Portugal

    Maria da Graça Maciel de Soveral & Miguel Babarro Jorreto

  • Laboratório de Imunologia e Biologia Molecular, Centro Hospitalar de Setúbal, Setúbal, Portugal

    Maria João Peres

  • Serviço de Patologia Clínica da Unidade Native de Saúde de Castelo Branco, Castelo Branco, Portugal

    Mariana Martins, Ricardo Rodrigues & Sandra Paulo

  • iBiMED/Universidade de Aveiro, Aveiro, Portugal

    Miguel Pinheiro

  • Departamento de Saúde Pública e Planeamento, ARS Alentejo, Évora, Portugal

    Paula Valente

  • Secretaria Regional de Saúde e Proteção Civil – Governo Regional da Madeira, Funchal, Portugal

    Pedro Ramos

  • Health center Agostinho Ribeiro-Felgueiras, Felgueiras, Portugal

    Sónia Marta Santos Magalhães

  • V.B., J.I., and J.P.G. designed the learn about. V.B. and J.I. carried out the pre-sequencing wet-lab procedures, genome meeting, curation and classification, and genetic and epidemiological information curation and integration. H.C.M. carried out metadata assortment and curation. H.M. supported information divulgation via putting in the general public website online. S.D., L.V., R.L., and I.G. carried out and/or supervised the wet-lab sequencing procedures. N.S.T. conceived and carried out the Bayesian phylodynamic analyses. N.S.T. retrieved the exterior genetic information and assembled the datasets. The consequences have been analyzed and interpreted via V.B., J.I., and N.S.T.; V.B., J.I., N.S.T., and J.P.G. wrote and reviewed the manuscript. All authors learn and authorized the general manuscript. All authors from the Portuguese community for SARS-CoV-2 genomics (Consortium) contributed to laboratory prognosis of SARS-CoV-2, pattern and knowledge assortment, and/or equipped recommendation on epidemiology and bioinformatics information research. R.G. supported pattern assortment and pre-sequencing wet-lab procedures. J.P.G. coordinated the learn about.

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