Uncommon COVID-19 vaccine-related blood clot mechanism exposed


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Researchers establish a molecular interplay between the COVID-19 vaccine adenovirus vector and platelet components that could be the reason for uncommon blood clots related to the vaccine. 

A global workforce of scientists from Cardiff College (UK) and Arizona State College (AZ, USA), along AstraZeneca (Cambridge, UK), have exposed a part of the mechanism concerned about extraordinarily uncommon blood clots related to the management of adenovirus COVID-19 vaccines. The analysis, led by means of first writer Alexander Baker (each Arizona State and Cardiff College), used CryoEM era to review the construction of the AstraZeneca vaccine adenovirus vector. The findings point out that the adenovirus can bind to platelet issue 4 (PF4), concerned about irritation and wound restore, and is also the reason for the uncommon blood clots. 



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